A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification

Frontiers in Public Health

Alessia Tognetto¹ 

关键词: colorectal cancer;    hereditary colorectal cancer;    Lynch syndrome;    immunohistochemistry;    microsatellite instability;    mismatch repair genes;    cancer prevention;    screening pathways;   

DOI  :  10.3389/fpubh.2017.00243

学科分类：卫生学

来源: Frontiers

【 摘 要 】

BackgroundLynch syndrome (LS) is the most common hereditary colon cancer syndrome, accounting for 3–5% of colorectal cancer (CRC) cases, and it is associated with the development of other cancers. Early detection of individuals with LS is relevant, since they can take advantage of life-saving intensive care surveillance. The debate regarding the best screening policy, however, is far from being concluded. This prompted us to conduct a systematic review of the existing screening pathways for LS.

【 授权许可】

CC BY