Similarity in Transcytosis of nNOSα in Enteric Nerve Terminals and Beta Cells of Pancreatic Islet

Frontiers in Medicine

Arun Chaudhury¹ 

关键词: nNOS;    myosin Va;    diabetes;    dimer;    LC8;   

DOI  :  10.3389/fmed.2014.00020

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Transcytosis of proteins and hydrodynamic flow of cytoplasm is a major mechanism to sustain physiology in all cells, observable from gametes (1) to mature adult cells and tissues (2, 3). Mammalian cells involved in secretion discretely need to respond to the environment and move components within the cells and position them at appropriate locations for secretion (4, 5). This process involves force generation using Gibbs free energy of hydrolysis of adenosine triphosphate (ATP). The ATPase is most often myosin, a naturally occurring cellular ATPase known for its wide role in generation of cellular force (6). The nanomechanics of transport involve the necessary target cargoes, in association with myosin and track on actin filaments, which are ubiquitous cellular cytoskeletal scaffolds of metazoan cells (7). Cellular secretion encompasses multiple physiological systems operating on wide range of time scales including the processes of exocrine and endocrine glandular secretions and neuronal secretion in response to discrete electrical field stimulation, commonly referred to as neurotransmission (8, 9).

【 授权许可】

CC BY