Erythropoietin Attenuates Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension through Interplay between Endothelial Progenitor Cells and Heme Oxygenase

Frontiers in Pediatrics

Rosa Laura E. van Loon¹ 

关键词: hemodynamics;    pulmonary vascular remodeling;    neointimal lesions;    aorto-caval shunt;    pulmonary hypertension;    right ventricular hypertrophy;   

DOI  :  10.3389/fped.2015.00071

学科分类：儿科学

来源: Frontiers

【 摘 要 】

BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts through mobilization of endothelial progenitor cells (EPCs) and activation of the cytoprotective enzyme heme oxygenase-1 (HO-1).

【 授权许可】

CC BY