Calcium-Activated Potassium Channels in Ischemia–Reperfusion: Learning for the Clinical Application

Frontiers in Medicine

Mohamed S. A. Mohamed¹ 

关键词: ex vivo lung perfusion;    lung transplantation;    ischemic–;    reperfusion injury;    Ca++-activated K+ channels;    inflammatory cytokines;    primary graft dysfunction;   

DOI  :  10.3389/fmed.2015.00021

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

The article by Tano and Gollasch published in Frontiers in Physiology reviewed the involvement of Ca++-sensitive K+ channels in ischemia and reperfusion, with cardio-vascular and brain models mostly discussed (1), where the increased Na+ inflow activates Na+–Ca++ exchanger, and leads to cell membrane depolarization (2). Activated Na+–Ca++ exchanger works to pump Na+ out and Ca++ in (2). The increase in intracellular Ca++ results in activation of various Ca++-sensitive K+ channels to establish K+ influx and hyperpolarization (1).

【 授权许可】

CC BY