Proteolytic cleavage of the long pentraxin PTX3 in the airways of cystic fibrosis patients:

Innate Immunity

YvelineHamon¹ 

关键词: Aspergillus fumigatus;    cystic fibrosis;    elastase;    pentraxin 3;   

DOI  :  10.1177/1753425913476741

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The prototypic long pentraxin PTX3, a soluble pattern recognition receptor, plays an important role in innate defense against selected pathogens by favoring their elimination and the initiation of protective responses. PTX3 has notably beneficial effects in mice infected with Aspergillus fumigatus and Pseudomonas aeruginosa. Cystic fibrosis (CF), a severe inherited autosomal recessive disease, is characterized by recurrent lung infections, especially by these two pathogens. We thus hypothesized that the status of PTX3 may be altered in CF patients. Level and integrity of PTX3 were analyzed in the sputum samples from 51 CF patients and 7 patients with chronic obstructive pulmonary disease (COPD). The levels of PTX3 were increased in serums from CF patients, but low in their respiratory secretions. PTX3 concentrations in sputum samples were dramatically lower in CF patients than in COPD patients. The low concentration of PTX3 resulted from a proteolysis cleavage by elastase and A. fumigatus proteases. Inter...

【 授权许可】

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