Role of high-risk human papillomavirus in the etiology of oral and oropharyngeal cancers in Thailand: A case–control study:

SAGE Open Medicine

AditChotipanich¹ 

关键词: Human papillomavirus;    human papillomavirus;    smoking;    oral cancer;    oropharyngeal cancer;    prevalence;    etiology;    Thail;   

DOI  :  10.1177/2050312118765604

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Among developing countries, Thailand shows no increase in the incidence of human papillomavirus–driven oropharyngeal cancer. The causal role of human papillomavirus infection in this pathology has not been researched thoroughly.Methods:A hospital-based, case–control study was performed which included 104 patients with newly diagnosed oral and oropharyngeal squamous cell carcinomas and 104 individuals without cancer. The Cervista high-risk human papillomavirus and 16/18 assays were used to detect human papillomavirus. Odds ratios were used to assess the association between high-risk genotypes of human papillomavirus and the cancers.Results:High-risk human papillomavirus was detected in 4 of 52 (7.7%) oral cancer cases, 6 of 52 (11.5%) oropharyngeal cancer cases, and 1 of 104 (0.96%) control subjects. Of 104 cancer patients in the study, 83 were smokers. High-risk human papillomavirus was significantly associated with oropharyngeal cancer (odds ratio = 13.44, 95% confidence interval = 1.6–114.8) ...

【 授权许可】

CC BY