Challenges in Managing EBV-Associated T- and NK-Cell Lymphoproliferative Diseases

Frontiers in Pediatrics

Yoshitaka Sato¹ 

关键词: EBV;    EBV-T/NK LPDs;    basic-preclinical research;    registry database;    CAEBV;   

DOI  :  10.3389/fped.2018.00320

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Epstein-Barr virus (EBV) infects >90% of adults worldwide and is closely linked to multiple B-cell malignancies, including Burkitt lymphoma, diffuse large B-cell lymphoma, Hodgkin lymphoma, and post-transplant lymphoproliferative disorder (PTLD) (1). Epstein-Barr virus also infects T-cells and natural killer (NK) cells causing EBV-associated T- and NK-cell (EBV-T/NK) malignancies, including extranodal NK/T-cell lymphomas, nasal type (ENKL), aggressive NK-cell leukemia, and lymphoproliferative diseases (LPDs). These EBV-associated T/NK-cell tumors have basically neoplastic properties with clonal proliferation and organ infiltration (2).

【 授权许可】

CC BY