Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR : what’s new and what’s enough

Cancer Communications

Fei Zhou¹  Cai-Cun Zhou¹ 

[1] Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, P. R. China

关键词: Epidermal growth factor receptor (EGRF);    EGFR mutation;    Anaplastic lymphoma kinase (ALK);    ALK rearrangement;    Molecular targeted therapy;    Non-small cell lung cancer;   

DOI  :  10.1186/s40880-015-0036-4

学科分类：肿瘤学

来源: Springer

【 摘 要 】

Historically, non-small cell lung cancer (NSCLC) is divided into squamous and nonsquamous subtypes based on histologic features. With a growing number of oncogenic drivers being identified in squamous and nonsquamous NSCLC, this malignancy has been recently divided into several distinct subtypes according to the specific molecular alterations. This new paradigm has substantially highlighted the treatment of advanced NSCLC, shifting it from standard chemotherapy according to specific histologic subtypes to targeted therapy according to specific oncogenic drivers. The application of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in NSCLC patients harboring activating EGFR mutations has been a representative model of precise medicine in the treatment of NSCLC. As the role of EGFR-TKIs in routine management of patients with advanced NSCLC has been well established, this review provides an overview of alternative targeted therapy in the treatment of NSCLC, including EGFR-TKIs for patients with wild-type EGFR NSCLC, as well as other targeted agents either clinical available or in early- to late-stage development.

【 授权许可】

CC BY