Preventive therapy with citalopram added to a beta blocker does not result in quality-of-life improvement in patients with episodic migraine:

Cephalalgia Reports

Juan CarlosGarcía-Monco¹ 

关键词: comorbidities;    depression;    migraine prevention;    quality of life;   

DOI  :  10.1177/2515816318813545

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:The quality of life of migraine patients, particularly mental domains, is severely diminished despite the preventive therapies available. We aimed to evaluate whether citalopram plus nadolol is superior to nadolol alone in terms of quality of life (QOL) in migraine patients.Methods:Adult patients with episodic migraine (≥ 3 headache days per month) were allocated by simple randomization to nadolol 40 mg daily plus citalopram 10 mg daily or to nadolol alone. Baseline visit confirmed the entry criteria and patients filled out a generic QOL (SF-36) as well a migraine-specific questionnaire (MSQoL), a measure of migraine-related disability (MIDAS), a headache calendar and Beck inventory for depression and anxiety. This battery was again completed after 16 weeks of therapy.Results:A total of 92 patients from a general neurology clinic completed the study, 85% females with migraine without aura. Fourty-four (47.83%) patients were allocated to nadolol therapy, and 48 (52.17%) to the combination of nad...

【 授权许可】

CC BY