The effect of pre-operative methylprednisolone on the incidence of delayed graft function in renal transplantation:

Proceedings of Singapore Healthcare

Nigel Jie MingFong¹ 

关键词: Renal transplantation;    induction of immunosuppression;    corticosteroids;    timing;    delayed graft function;    eGFR;   

DOI  :  10.1177/2010105816629753

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Introduction:This study explores the effect of different corticosteroid administration timings on the incidence of slow/delayed graft function.Methods:One hundred and twelve kidney transplants from January 2011 to March 2014 were retrospectively analysed. Thirty-six cases were excluded because they were donor-specific antibody positive (n=16), received thymoglobulin/plasma exchange (n=11), were ABO-incompatible (n=6) or suffered graft loss from vascular thrombosis within the first week post-transplant (n=3). The study period straddled three eras of corticosteroid administration, from intra-operative intravenous (IV) hydrocortisone (Era 1; n=26), to intra-operative IV methylprednisolone (Era 2; n=38) and pre-operative IV methylprednisolone (Era 3; n=12). The primary endpoint was the incidence of slow/delayed graft function. Secondary outcomes included estimated glomerular filtration rate at discharge and 120 and 365 days, rejection (acute and one-year), wound complications, post-transplant diabetes, increa...

【 授权许可】

CC BY