Changes in the viability of Strongyloides ransomi larvae (Nematoda, Rhabditida) under the influence of synthetic flavourings

Regulatory Mechanisms in Biosystems

A. A. Boyko¹  V. V. Brygadyrenko² 

[1] Dnipropetrovsk State Agrarian-Economic University;Oles Honchar Dnipropetrovsk National University

关键词: нематоды;   

DOI  :  10.15421/021707

学科分类：自然科学（综合）

来源: Oles Honchar Dnipro National University

【 摘 要 】

One of the most common nematodes of pigs globally is Strongyloides ransomi Schwartz and Alicata 1930. It usually causes aggravation of physiological indicators of its hosts and damage to their immune system. Also it is a good modelling object for the evaluation of the antiparasitic activity of new antihelminthic drugs. We conducted laboratory experiments to assess the effect of flavouring additives with flower odour (benzaldehyde, citral, D-limonene and β-ionone) upon the viability of S. ransomi larvae. The mortality rate was calculated for 24 hours exposure at four concentrations of each substance (10, 1, 0.1 и 0.01 g/l) with eight replications. The lowest LD50 values were obtained for citral (97 mg/l) and benzaldehyde (142 mg/l). These substances are recommended for further evaluation of their antihelminthic effect in experiments using laboratory animals. Unlike other substances, the effect of β-ionone and D-limonene even at a concentration of 10 g/l after 24 hours caused the death of <50% of S. ransomi larvae. The study of flavouring additives with flowery odour, which are permitted to be used in food for humans and also to be used in cosmetics, is a promising field for research aimed at the development of new antiparasitic drugs. .

【 授权许可】

CC BY