Cost-description and multiple imputation of missing values: the SATisfaction and adherence to COPD treatment (SAT) study:

Global & Regional Health Technology Assessment

CarloLazzaro¹ 

关键词: COPD;    Italy;    SAT study;    cost description;    multiple imputation;   

DOI  :  10.1177/2284240318788877

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Aim:This article reports on a retrospective quarterly cost description (CD) performed on 401 patients with stable chronic obstructive pulmonary disease (COPD) at enrolment in the national, multicenter, noninterventional SATisfaction and adherence to COPD treatment (SAT) study.Methods:Examined from the perspective of the Italian National Health Service, health care resources were costed via published sources and expressed in euro (€) 2017 on a per patient basis. Incomplete data were addressed via multiple imputation (MI) with 20 completed datasets.Results:384 patients were evaluable (moderate COPD: 76.00%). Most patients (61.47%) reported no COPD exacerbations during the year before the enrolment. Under Available Case Analysis the mean quarterly cost was €328.59 (standard deviation – SD: €537.25); 187 patients (48.69%) reported missing completely at random (MCAR) or missing at random (MAR) data. Their mean quarterly cost (€191.30; SD: €356.86) was significantly lower (bootstrap p-value < 0.0001) than that ...

【 授权许可】

CC BY