Time related effects of non-steroidal anti-inflammatory drugs on Achilles tendinopathy in a murine model:

Foot & Ankle Orthopaedics

AdamBitterman¹ 

关键词: Achilles tendon;    tendinosis;    inflammation;    scarring;    fibrosis;    healing;    tendinopathy;    ibuprofen;   

DOI  :  10.1177/2473011417S000002

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/BiologicsIntroduction/Purpose:Tendinopathy has been identified to result from work and sports-related activities, in many patients. Common treatment for such degenerative tendon pathology includes non-steroidal anti-inflammatory drugs (NSAIDs). Although they provide pain relief, their mechanistic effects, on modulating inflammation associated with tendinopathy is poorly understood. Recent reports suggest impaired functional healing of rat rotator cuff tear repairs when treated in the early postoperative period with ibuprofen, while delayed treatment did not affect healing. We have now identified, using a murine model, a cascade of genes associated with innate inflammation, which influence premature fibrotic scarring without repair. The objective of this study was to evaluate the effects of orally administered ibuprofen on inflammation and wound-healing responses after initiation and during progression of Achilles tendinopathy in a murine model.Methods:All animal experimentation was...

【 授权许可】

CC BY