Lung Cancer Mortality in the Lung Screening Study Feasibility Trial

JNCI Cancer Spectrum

Marcus, Pamela M¹  Doroudi, Maryam²  Pinsky, Paul F² 

[1] Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD;Division of Cancer Prevention, National Cancer Institute, Bethesda, MD

关键词: lung;    mortality;    lung cancer;    lung cancer screening;    follow-up;    cancer;    chest x-ray;    participation in ward rounds;    low-dose spiral ct;   

DOI  :  10.1093/jncics/pky042

学科分类：肿瘤学

来源: Oxford University Press

【 摘 要 】

The Lung Screening Study was a multicenter controlled feasibility trial that randomly assigned subjects to undergo two rounds of screening with either low-dose spiral computed tomography (LDCT) or chest X-ray (CXR). Long-term follow-up was performed to evaluate any differences in lung-cancer-specific and all-cause mortality between arms. In 2000, subjects were randomly assigned at six screening centers. Linkage with the National Death Index was performed to ascertain long-term mortality for subjects. Median follow-up for mortality of the 1660 and 1658 subjects randomly assigned to LDCT and CXR, respectively, was 5.2 years. There were 32 and 26 deaths from lung cancer in the two groups, respectively, corresponding to lung cancer death rates of 3.84 and 3.10 per 1000 person-years, and a risk ratio of 1.24 (95% confidence interval = 0.74 to 2.08). The risk ratio for all-cause mortality was 1.20 (95% confidence interval = 0.94 to 1.54). These findings can contribute to the overall knowledge on LDCT lung cancer screening.

【 授权许可】

CC BY-NC-ND