Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity:

Innate Immunity

Kinga K.Hosszu¹ 

关键词: dendritic cells;    complement;    C1q;    C1q receptors;    innate immunity;   

DOI  :  10.1177/1753425909339815

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Growing evidence shows that C1q modulates the growth and function of cells committed to the monocyte-derived dendritic cell (DC) lineage. Because C1q regulates both innate and acquired immune responses, we postulated that C1q modulates the transition from monocytes to DCs, i.e. the interface between innate and acquired immunity. Human peripheral blood monocytes cultured with soluble C1q and DC growth factors (granulocyte-macrophage colony-stimulating factor + Interleukin-4) failed to down-regulate monocyte-associated (CD14, CD16) and up-regulate DCassociated (CD83, CD86) markers. Impaired DC differentiation was not due to apoptosis; further analysis revealed the development of CD14hiCD11chiCD16 +/— cells that have previously been associated with both innate and acquired immunity. Monocyte—DC precursors expressed gC1qR, the receptor for globular heads of C1q, from the outset, while cC1qR, the receptor for the collagen tails of C1q, was expressed at low levels. Notably, the binding pattern of monoclonal ant...

【 授权许可】

CC BY