БЕЛКИ МЕМБРАНЫ ЭРИТРОЦИТОВ И ПОКАЗАТЕЛЬ СФЕРИЧНОСТИ У БОЛЬНЫХ ЭССЕНЦИАЛЬНОЙ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ, ОСЛОЖНЁННОЙ И НЕ ОСЛОЖНЁННОЙ МЕТАБОЛИЧЕСКИМ СИНДРОМОМ

Acta Biomedica Scientifica

О. В. Богданова¹  Л. А. Дмитриева¹  Ю. И. Пивоваров¹  А. С. Сергеева¹ 

[1] ФГБНУ «Иркутский научный центр хирургии и травматологии»

关键词: белки;    мембрана эритроцитов;    показатель сферичности;    метаболический синдром;    артериальная гипертензия;   

DOI  :  10.12737/article_5955e6b44604e4.78416241

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Change in structural and functional properties of red cell membrane proteins in patients with the essential arterial hypertension (EAH) can promote development of significant dysfunction of these cells and can complicate the course of a system hypoxia in this category of patients. The aim of our research was to determine the interrelation between red cell sphericity and the level of proteins of their membrane in patients with EAH complicated and non-complicated with metabolic syndrome (MS). 51 male patients with EAH I and II (average age - 42 ± 1.5 years) were examined and divided into 2 groups: group 1 - 29 patients with EAH complicated with MS; group 2 - 22 patients with EAH non-complicated with MS. Protein spectrum was assessed by 10 red cell membrane proteins. Results. Patients with EAH complicated with MS had decrease in spectrin level and loss of correlations between the levels of red cell membrane proteins. Number of patients with diameter-thickness ratio < 3.4 (indicates the existence of cells prone to spherocytosis) in the group 1 was twice more than in the group 2 (29.4 % vs 13.7 %). Conclusion. We determined structural and functional disorders in interrelations of such membrane proteins as a-spektrin, ATP and GAPDH (in patients with EAH complicated with MS), and ATP, GAPDH and actin (in patients with EAH non-complicated with MS) which promote development of acquired spherocytosis and further impairments in microcirculation and gaseous metabolism in tissues.

【 授权许可】

CC BY