Pediatric Nephrology in Primary Care: The Forest for the Trees

Frontiers in Public Health

Donald E. Greydanus¹ 

关键词: pediatrics;    nephrology;    primary care;    kidney;    public health;   

DOI  :  10.3389/fpubh.2015.00227

学科分类：卫生学

来源: Frontiers

【 摘 要 】

As we carefully cast our eyes though the keyhole of science, one can see more wondrous advances in nephrology as this twenty-first century unwinds based on the work of previous scholars (Table ​(Table1)1) (2, 4). More understanding will develop in the complex interactions of vitamin D and the kidney based on the 1973 synthesis of 1,25(OH)2 vitamin D (4–6). Rickets was identified in the first part of the twentieth century and research on this defective disorder of mineralization will reach further progress (4). Mutations in podocyte genes were shown in the twentieth century to lead to renal dysfunction from hereditary podocytopathies that has opened up an active vein of study in this century (4, 7). The twentieth century Human Genome Project (HGP) has energized intense inquisition on genetic causes of renal disease and genetic testing in renal disease in this century with work on total human exome capture, next-generation sequencing, gene regulatory networks (GRN), genome-wide association studies (GWAS), the role of micro-RNAs (miRNAs) in renal disease, genotype-based risk prediction, and individualized genetic treatments (4, 8–11).

【 授权许可】

CC BY