Role of the Cingulate Cortex in Dyskinesias-Reduced-Self-Awareness: An fMRI Study on Parkinson’s Disease Patients

Frontiers in Psychology

Sara Palermo¹ 

关键词: Parkinson’;    s Disease;    dyskinesias;    self-awareness;    response-inhibition;    fMRI;   

DOI  :  10.3389/fpsyg.2018.01765

学科分类：心理学（综合）

来源: Frontiers

【 摘 要 】

Objectives: The detection of dyskinesias-reduced-self-awareness (DRSA), in Parkinson’s disease (PD), was previously associated to executive and metacognitive deficits mainly due to dopaminergic overstimulation of mesocorticolimbic circuits. Response-inhibition dysfunction is often observed in PD. Apart from being engaged in response-inhibition tasks, the anterior cingulate cortex (ACC), is part of a functional system based on self-awareness and engaged across cognitive, affective and behavioural contexts. The purpose of the study was to examine the relationship between response-inhibition disabilities and DRSA using whole-brain event-related functional magnetic resonance imaging (fMRI), over the course of a specific executive task.

【 授权许可】

CC BY