Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study:

SAGE Open Medicine

DuanLiu¹ 

关键词: Amnestic mild cognitive impairment;    diffusion tensor imaging;    atlas-based analysis;    cognitive function;   

DOI  :  10.1177/2050312116648812

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objective:This study investigated white matter integrity in patients with amnestic mild cognitive impairment by diffusion tensor imaging.Methods:A total of 83 patients with amnestic mild cognitive impairment and 85 elderly healthy controls underwent neuropsychological testing and a diffusion tensor imaging scan. Whole-brain white matter data were parcellated into 50 regions based on the anatomical ICBM-DTI-81 atlas, and regional diffusion metrics consisting of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity were calculated for each region. Diffusion tensor imaging indices were compared between groups, and it was determined that between-group differences were significantly correlated with neurocognitive performance.Results:Relative to the healthy controls group, the amnestic mild cognitive impairment group exhibited poorer cognitive performance in all neuropsychological tests except the complex figure test (p = 0.083) and showed decreased mean fractional anisotropy in the...

【 授权许可】

CC BY