Effective molecules of some natural product as antidepressant and antihistamine drugs: A NMR study

Ukrainian Journal of Ecology

Majid Monajjemi¹  Mina Zakeri² 

[1] Department of Chemical Engineering, Central Tehran branch, Islamic Azad University;Department of Chemistry, Science and Research Branch, Islamic Azad University

关键词: S-NICS;    NICS;    Luteolin;    Buclizine;    Myriceti;    formononetin;    Cetirizine;   

DOI  :  10.15421/2018_335

学科分类：生物科学（综合）

来源: Alex Matsyura Publishing

【 摘 要 】

Due to increasing rates of depression in recent years, the use of the drug-plants is significantly important. In this work, we have optimized and discussed about several active compounds which are extracted from famous plants such as formononetin (a constituent of Cimicifuga racemosa), Luteolin (fromPerilla frutescens), Myriceti (Clitoria ternatea) and Piper methysticum as antidepressant and antihistamine through NMR study.There are no works in theoretical of a statistical approach in NMR shielding and nucleus independent chemical shifts for study of antidepressant and antihistamine drugs, while the asymmetry(η) and skew(κ) parameters are fluctuated in small distances and are alternative in large distances in the center of heterocyclic rings for Luteolin, Buclizine, Myriceti, formononetin and  Cetirizine. By changing asymmetry between 0 ≤η≤+1 skew will be changed between -1 ≤κ ≤+1 , meanwhile the parameter κ is zero when σ 22= σ iso15 .In the case of axially-symmetric tensor, σ 22equals either σ 11or σ 33 , skew is κ = ±1. In this work, we have investigated the statistical methods by computing of nucleus-independent chemical shifts-SNICS in point of Bq motions in the center of sphere in shielding and de-shielding spaces of antidepressant and antihistamine drugs. .

【 授权许可】

CC BY