Pregnancy as a Possible Trigger for Heritable Pulmonary Arterial Hypertension:

Pulmonary Circulation

MaudeLimoges¹ 

关键词: pulmonary arterial hypertension;    pregnancy;    right ventricle;    BMPR2;   

DOI  :  10.1086/686993

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

It is unclear whether pregnancy is a trigger or accelerant for idiopathic pulmonary arterial hypertension (PAH). Alternatively, its frequency close to the onset of symptoms and diagnosis in the idiopathic PAH population may represent a coincidence in a disease that predominates in young women. We describe a carrier of a BMPR2 gene mutation who had an uneventful first pregnancy but had aggressive PAH during her second pregnancy and now has ongoing heritable PAH. The possible role of pregnancy as a trigger in this vulnerable patient is discussed. Databases of patients with heritable PAH should be explored to see whether pregnancy is related to overt manifestation of the disease.

【 授权许可】

CC BY