Application of Amniotic Membrane Improves Repair in a Diabetic Animal Model for Delayed Tendon Healing:

Foot & Ankle Orthopaedics

NormanWaldrop¹ 

关键词: Amniotic Membrane;    Diabetes;    Tendon;   

DOI  :  10.1177/2473011417S000082

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Category:Basic Sciences/Biologics, DiabetesIntroduction/Purpose:Tendon injuries often heal with significant scar formation and compromised biomechanical function. For diabetics, these injuries are further complicated by changes in the extracellular matrix of the tendon, leading to higher incidences of injury and slower healing. Defective or delayed healing is a result of several factors including an impaired ability to form a collagen matrix, compromised angiogenesis, and inadequate production of growth factors. Consequently, complications and re- rupture rates are higher in diabetic patients. Amnion-derived cells resulted in improved tendon healing in an otherwise healthy animal model, in part due to their ability to provide numerous regenerative cytokines to the repair site. The purpose of this study was to evaluate the effect of amniotic tissues on tendon healing in a diabetic model with impaired healing.Methods:For this study BBZDR/WOR animals, an insulin dependent Type II diabetic rodent model, were ...

【 授权许可】

CC BY