Bronchopulmonary Dysplasia Early Changes Leading to Long-Term Consequences

Frontiers in Medicine

Anne Hilgendorff¹ 

关键词: bronchopulmonary dysplasia;    neonatal chronic lung disease;    lung development;    long-term consequences;    hyperoxia;    mechanical ventilation;    inflammation;    animal models;   

DOI  :  10.3389/fmed.2015.00002

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Neonatal chronic lung disease, i.e., bronchopulmonary dysplasia, is characterized by impaired pulmonary development resulting from the impact of different risk factors including infections, hyperoxia, and mechanical ventilation on the immature lung. Remodeling of the extracellular matrix, apoptosis as well as altered growth factor signaling characterize the disease. The immediate consequences of these early insults have been studied in different animal models supported by results from in vitro approaches leading to the successful application of some findings to the clinical setting in the past. Nonetheless, existing information about long-term consequences of the identified early and most likely sustained changes to the developing lung is limited. Interesting results point towards a tremendous impact of these early injuries on the pulmonary repair capacity as well as aging related processes in the adult lung.

【 授权许可】

CC BY