Особенности процессов липопероксидации и антиоксидантной защиты у мужчин-монголоидов, носителей нефункциональных полиморфизмов генов GSTT1 и GSTM1, с различным статусом фертильности

Acta Biomedica Scientifica

Б. Г. Дашиев¹  А. В. Лабыгина²  Л. И. Колесникова³  Т. А. Баирова⁵  Е. В. Осипова⁵  Н. А. Курашова⁵  И. Н. Гутник⁵  М. И. Долгих⁵  И. М. Михалевич⁶ 

[1] ФГБОУ ВО «Иркутский государственный университет»;ГАУЗ «Республиканский перинатальный центр»;Иркутская государственная медицинская академия последипломного образования - филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России;ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»;ФГБНУ «научный центр проблем здоровья семьи и репродукции человека»;ФГБОУ ВО «Иркутский государственный университет»

关键词: окислительный стресс;    мужчины;    бесплодие;   

DOI  :  10.29413/ABS.2018-3.3.19

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Background. Genetic factors cause 30-50 % of cases of male infertility different forms. We have conducted the investigation of the lipid peroxidation and antioxidant protection system components, associated with the biotransformation genes polymorphisms, in men with infertility. Aims: to study parameters of lipid peroxidation and antioxidant defense system associated with polymorphisms of biotransformation genes in infertile Mongoloid men. Materials and methods. The main group included 143 men of reproductive age from Mongoloid population who came to the Public Health Institution "Republican Perinatal Center" in Ulan-Ude with the problem of one year and more infertility after the marriage. Fifty-three almost healthy males with proven fertility were included in the control group. Blood samples of all men were genotyped by glutathione S-transferase (GSTP1, GSTM1, GSTT1) gene family and activity of glutathione system enzymes was determined. Results. In the fertile Mongoloids with non-functional genotype GSTT1(0/0)/GSTM1(0/0) we have established an increase concentration of a-tocopherol in serum, activity of glutathione peroxidase and a decrease in glutathione-S-transferase, as well as a decrease in the concentration of a-tocopherol. In infertile Mongoloids with non-functional GSTT1(0/0)/ GSTM1 (0/0) genotypes, an increase in the tiobarbituric acid reactants, glutathione peroxidase and a decrease in the concentration of a-tocopherol was found in the ejaculate; we also detected a decrease in the concentration of a-tocopherol, the level of oxidized glutathione and glutathione-s-transferase activity. Conclusions. Genetically determined peculiarities of functioning of the xenobiotic biotransformation system make each individual unique with regard to their adaptive capacity - resistance or sensibility to the damaging exo- and endogenous factors.

【 授权许可】

CC BY