Genetic Influences on the Development of Fibrosis in Crohn’s Disease

Frontiers in Medicine

Bram Verstockt¹ 

关键词: stricturing disease;    fibrosis;    Crohn’;    s disease;    genetics;    NOD2;   

DOI  :  10.3389/fmed.2016.00024

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Fibrostenotic strictures are an important complication in patients with Crohn’s disease (CD), very often necessitating surgery. This fibrotic process develops in a genetically susceptible individual and is influenced by an interplay with environmental, immunological, and disease-related factors. A deeper understanding of the genetic factors driving this fibrostenotic process might help to unravel the pathogenesis, and ultimately lead to development of new, anti-fibrotic therapy. Here, we review the genetic factors that have been associated with the development of fibrosis in patients with CD, as well as their potential pathophysiological mechanism(s). We also hypothesize on clinical implications, if any, and future research directions.

【 授权许可】

CC BY