Мукоцилиарный транспорт и микробиота полости носа, околоносовых пазух при хроническом риносинусите, ассоциированном с гастроэзофагеальной рефлюксной болезнью

Acta Biomedica Scientifica

М. В. Субботина¹  Е. В. Онучина²  И. В. Темникова³ 

[1] ГБОУ ВПО «Иркутский государственный медицинский университет»;ГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» Минздрава России;НУЗ «Дорожная клиническая больница на станции Иркутск-Пассажирский ОАО «РЖД»

关键词: хронический риносинусит;    гастроэзофагеальная рефлюксная болезнь;    микробиота;    мукоцилиарный транспорт;    сhronic rhinosinusitis;   

DOI  :  10.12737/article_590823a47345c8.15562147

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

The aim of our investigation was to estimate the mucociliary clearance (MC), the spectrum of bacterial communities discharged from the middle meatus and sinus aspirates in patients with chronic rhinosinusitis (CRS) associated with gastroesophageal reflux disease (GERD), patients with CRS without GERD and healthy volunteers. The study included 30 patients with CRS and GERD, 34 patients without GERD аnd 30 healthy volunteers. Association with CRS and GERD was characterized by statistically significant slowing of MC and quantitative and qualitative changing of characteristics of the nasal mucosa microflora, but not of the paranasal sinuses. In the group of patients with CRS with GERD, MC amounted to 28.5 ± 4.7 min, in the group without GERD - 23.6 ± 2.7 min, in the healthy group - 5.8 ± 1 min. S. аureus (р = 0.009), E. mli (р = 0.029) and Candida albicans (р = 0.013) were detected in the mucosa of the middle meatus of patients with CRS and GERD more than in patients with CRS without GERD. No significant differences in the microflora of the paranasal sinus aspirate were revealed.

【 授权许可】

CC BY