PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegans:

Innate Immunity

YiXiao¹ 

关键词: PKA;    Salmonella enterica;    C. elegans;    innate immunity;    antimicrobial effector;    autophagy;   

DOI  :  10.1177/1753425917732822

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

The genetically tractable organism Caenorhabditis elegans is a powerful model animal for the study of host innate immunity. Although the intestine and the epidermis of C. elegans that is in contact with pathogens are likely to function as sites for the immune function, recent studies indicate that the nervous system could control innate immunity in C. elegans. In this report, we demonstrated that protein kinase A (PKA)/KIN-1 in the neurons contributes to resistance against Salmonella enterica infection in C. elegans. Microarray analysis revealed that PKA/KIN-1 regulates the expression of a set of antimicrobial effectors in the non-neuron tissues, which are required for innate immune responses to S. enterica. Furthermore, PKA/KIN-1 regulated the expression of lysosomal genes during S. enterica infection. Our results suggest that the lysosomal signaling molecules are involved in autophagy by controlling autophagic flux, rather than formation of autophagosomes. As autophagy is crucial for host defense agains...

【 授权许可】

CC BY