Effects of a health education program on cytokines and cortisol levels in fibromyalgia patients: a randomized controlled trial

Advances in Rheumatology

Janaí¹  Andrei Pereira Pernambuco²  Á²  Renato de Souza Viana⁴  Luana Pereira Leite Schetino⁵  bora d’⁶  Dé⁷  vila Reis⁸  Lucina de Souza Cota Carvalho⁸  ne Cunha Polese⁹ 

[1] Centro UniversitáDepartamento de Morfologia, Instituto de CiêHospital Mater Dei, Belo Horizonte, Brazil;Universidade de Itaúgicas da Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil;na, Brazil;na, Itaúncias Biolório de Formiga, Formiga, Brazil

关键词: Fibromyalgia;    Health education program;    Treatment;    Cortisol;    Cytokines;   

DOI  :  10.1186/s42358-018-0022-z

学科分类：过敏症与临床免疫学

来源: Springer

【 摘 要 】

Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain associated to other symptoms, such as: fatigue, anxiety, depression and sleep disorders. Health education programs (HEP) have emerged as good non-pharmacological strategies to treat it. However, it is still not clear if the benefits are only subjective, or it has also objective impacts on immune and or neuroendocrine systems. Fifty-eight fibromyalgia women were randomly allocated in experimental group (n = 27) or control group (n = 31). The experimental group was submitted to HEP treatment for 11 weeks, while control group did not receive intervention at the same period. All data were collected at zero and 11th week by a blinded researcher. The statistical analysis were made in GraphPad Prism software (version 5.0) with significant level adjusted for α = 0.05. Forty-four patients concluded the full study, 21 in the experimental group and 23 in the control group. Intragroup and intergroup analysis revealed that treatment induced significant increases of IL-4 plasma levels, anti-inflammatory cytokine/inflammatory cytokine ratio (AC/IC ratio), salivary cortisol levels, in addition to significant decreases on FIQ scores. Intergroup variation analyses revealed also significant increases of IL-10 plasma levels. The results presented suggest that this kind of HEP could induce subjective and objective changes (immune and neuroendocrine), that could explain, at least in part the improvement of fibromyalgia patient’s health status. (Clinical Trial Registration Number - ReBEC - RBR-5tdnbr).

【 授权许可】

CC BY