New IL-15 receptor-α splicing variants identified in intestinal epithelial Caco-2 cells:

Innate Immunity

CeliaEscudero-Hernández¹ 

关键词: Alternative splicing;    cancer;    disease;    epigenetics;    interleukin-15;   

DOI  :  10.1177/1753425916674263

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

IL-15 is a pleiotropic cytokine related to IL-2 which acts at a broader level than its counterpart. It is presented through its specific high-affinity receptor, IL-15Rα. Both cytokine and receptor are tightly regulated at multiple levels and are widely distributed. Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15Rα have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15Rα in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer.

【 授权许可】

CC BY