Случаи тяжелого Clostridium difficile-ассоциированного псевдомембранозного колита, протекающего с симптомами перитонита

Acta Biomedica Scientifica

Е. И. Белинская¹ 

[1] ОГУАЗ «Иркутская городская клиническая больница № 1»; ГБОУ ВПО «Иркутский государственный медицинский университет» Минздрава России; ФГБОУ ВПО «Санкт-Петербургский государственный университет»

关键词: псевдомембранозный колит;    инфекция Clostridium difficile;    перитонит;   

DOI  :  

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Recently there was an increase of Clostridium difficile infection cases with the development of severe pseudomembranous colitis with high mortality and high percentage of backsets. Major reason for this growing problem is the emergence of newer, more virulent and more antibiotic-resistant strains including PCR ribotype 027. The major risk factors for pseudomembranous colitis are hospitalizing, antibiotics exposure, chemotherapy, use of proton-pumps inhibitors, older age, concomitant diseases. The appearance of diarrhea, acute abdominal pain, leukocytosis, hypoproteinemia after antibiotic therapy should be considered as a basis for targeted diagnostics of pseudomembranous colitis with the use of laboratory tests. Fulminant pseudomembranous colitis occurs in 5 % of patient with Clostridium difficile infection. This patients often have severe abdominal pain and can have signs of peritonitis and a markedly increased white blood cells. Colectomy should be considered in patients with fulminant colitis. The mortality rate in fulminant pseudomembranous colitis is up to 70 %. The basis for the prevention of pseudomembranous colitis is a rational prescription of antibacterial agents.

【 授权许可】

CC BY