Translating GWAS Findings to Novel Therapeutic Targets for Coronary Artery Disease

Frontiers in Cardiovascular Medicine

Le Shu¹ 

关键词: genome-wide association study;    coronary artery disease;    drug targets;    multi-omics;    functional genomics;    networks;   

DOI  :  10.3389/fcvm.2018.00056

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

The success of genome-wide association studies (GWAS) has significantly advanced our understanding of the etiology of coronary artery disease (CAD) and opens new opportunities to reinvigorate the stalling CAD drug development. However, there exists remarkable disconnection between the CAD GWAS findings and commercialized drugs. While this could implicate major untapped translational and therapeutic potentials in CAD GWAS, it also brings forward extensive technical challenges. In this review we summarize the motivation to leverage GWAS for drug discovery, outline the critical bottlenecks in the field, and highlight several promising strategies such as functional genomics and network-based approaches to enhance the translational value of CAD GWAS findings in driving novel therapeutics.

【 授权许可】

CC BY