Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia

Frontiers in Cardiovascular Medicine

Sachiko Nishimoto¹ 

关键词: hind-limb ischemia;    blood flow recovery;    Toll-like receptor 9;    inflammation;    macrophage;   

DOI  :  10.3389/fcvm.2018.00144

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

Background: Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue injury releases various endogenous ligands for Toll-like receptors (TLRs), suggesting the involvement of TLRs in blood flow recovery. However, the role of TLR9, which was originally known as a sensor for bacterial DNA, remains unknown. This study investigated the role of TLR9 in blood flow recovery in the ischemic limb using a mouse hind-limb ischemia model.

【 授权许可】

CC BY