Procyanidin B2 prevents lupus nephritis development in mice by inhibiting NLRP3 inflammasome activation:

Innate Immunity

JunhuiHe¹ 

关键词: Lupus nephritis;    procyanidin B2;    renal damage;    NLRP3 inflammasome;    anti-inflammation;   

DOI  :  10.1177/1753425918780985

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Lupus nephritis (LN) is a multifactorial event that contributes to the long-term mortality of systemic lupus erythematosus (SLE). Activation of NLRP3 inflammasome has been known to play a role in SLE pathogenesis. We evaluated the renal protection effects of procyanidin B2 (PCB2) and the involvement of NLRP3 in a mouse model involving MRL/lpr and MRL/MpJ mice. Kidney injury was evaluated by measuring the renal clinical and pathological features, renal immune complex deposition, and serum anti-double-stranded (anti-dsDNA) Abs. ELISA and Western blotting were used to detect NLRP3 inflammasome activation and IL-1β/IL-18 production. NLRP3 gene silencing was introduced into MRL/lpr mice by short hairpin RNA, and the renal damage was compared with the treatment of PCB2. PCB2 remarkably reduced renal damage in MRL/lpr mice, reflected by the reduced proteinuria, and serum levels of blood urea nitrogen and creatinine, as well as pathological features with less renal injury. PCB2 significantly reduced renal immune ...

【 授权许可】

CC BY