Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response:

Innate Immunity

NikolaosMavrogiorgos¹ 

关键词: Innate immunity;    NOD-like receptors;    Neisseria gonorrhoeae;   

DOI  :  10.1177/1753425913493453

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

NOD1 and NOD2 are members of the NOD-like receptor family of cytosolic pattern recognition receptors that recognize specific fragments of the bacterial cell wall component peptidoglycan. Neisseria species are unique amongst Gram-negative bacteria in that they turn over large amounts of peptidoglycan during growth. We examined the ability of NOD1 and NOD2 to recognize Neisseria gonorrhoeae, and determined the role of NOD-dependent signaling in regulating the immune response to gonococcal infection. Gonococci, as well as conditioned medium from mid-logarithmic phase grown bacteria, were capable of activating both human NOD1 and NOD2, as well as mouse NOD2, leading to the activation of the transcription factor NF-κB and polyubiquitination of the adaptor receptor-interacting serine-threonine kinase 2. We identified a number of cytokines and chemokines that were differentially expressed in wild type versus NOD2-deficient macrophages in response to gonococcal infection. Moreover, NOD2 signaling up-regulated com...

【 授权许可】

CC BY