Динамика функции почек у пациентов с фибрилляцией предсердий: взаимосвязи с системным фиброзом и жёсткостью сосудистой стенки

Acta Biomedica Scientifica

К. В. Протасов¹  В. З. Доржиева¹ 

[1] Иркутская государственная медицинская академия последипломного образования - филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

关键词: фибрилляция предсердий;    хроническая болезнь почек;    скорость клубочковой фильтрации;    матриксная металлопротеиназа-2;    трансформирующий фактор роста-β1;    центральное пульсовое давление;   

DOI  :  10.29413/ABS.2018-3.1.1

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

The aim was to study the dynamics of renal function in relation to the fibrosis activity and the arterial stiffness in young and middle-aged patients with atrial fibrillation (AF). Materials and methods. 50 young and middle-aged men with AF were examined. The average age was 53.0 (48.0-58.0). The serum levels of creatinine and cystatin C (Cys C) were determined and the glomerular filtration rate (eGFR) was calculated initially and after 12 months. The activity of systemic fibrosis was assessed by serum metalloproteinase-2 (MMP-2) and transforming growth factor-ß1 (TGF-ß1) determining. To assess systemic vascular stiffness central aortic pressure and pulse wave velocity (PWV) were measured. Results. Renal impairment defined as eGFR decrease by more than 10 ml/min/1.73 m 2or to the level below than 60 ml/min/1.73 m 2throughout the year was registered in 10 (20.0 %) patients. The concentration of MMP-2 and TGF-ß1 was higher in the subgroup with the eGFR decline compared to the patients without renal function impairment (21.1 (17.4-25.9) and 16.5 (13.0-19.2) ng/ml (p = 0.038); 3.01 (0.09-17.4), and 0.08 (0-1.3) ng/ml (p = 0.041). Central aortic pulse pressure was also higher in the patients with eGFR decline (45.5 (42.0-49.0) and 38.0 (31.0-41.0) mmHg; p = 0.036). The PWV levels did not differ in the subgroups. Conclusion. The renal function impairment throughout a follow-up period of 12 months was registered in 20.0 % of young and middle-aged patients with AF. This subgroup of AF patients was characterized by increased activity of systemic fibrosis and vascular stiffness in terms of matrix metalloproteinase-2, transforming growth factor-ß1 and central aortic pulse pressure levels.

【 授权许可】

CC BY