High variability of TLR4 gene in different ethnic groups in Iran:

Innate Immunity

MihaiIoana¹ 

关键词: Pattern recognition receptors;    TLR4;    Asp299Gly;    Thr399Ile polymorphisms;    genetic drift;    Iran;   

DOI  :  10.1177/1753425911423043

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Infectious diseases exert a constant evolutionary pressure on the innate immunity genes. TLR4, an important member of the TLR family, specifically recognizes conserved structures of various infectious pathogens. Two functional TLR4 polymorphisms, Asp299Gly and Thr399Ile, modulate innate host defense against infections, and their prevalence between various populations has been proposed to be influenced by local infectious pressures. If this assumption is true, strong local infectious pressures would lead to a homogeneous pattern of these ancient TLR4 polymorphisms in geographically-close populations, while a weak selection or genetic drift may result in a diverse pattern. We evaluated TLR4 polymorphisms in 15 ethnic groups in Iran, to assess whether infections exerted selective pressures on different haplotypes containing these variants. The Iranian subpopulations displayed a heterogeneous pattern of TLR4 polymorphisms, comprising various percentages of Asp299Gly and Thr399Ile, alone or in combination. The...

【 授权许可】

CC BY