The contribution and attitudes of research ethics committees to complete registration and non-selective reporting of clinical trials: A European survey:

Research Ethics

DanielStrech¹ 

关键词: Europe;    publication bias;    registration;    reporting;    research ethics committees;   

DOI  :  10.1177/1747016115626497

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background: For many years, studies have shown that the results of clinical trials are often published or reported selectively with a statistically significant bias in favour of positive trial results. Trial registration as a precondition for publication had only limited effects on current practice. Results of trials which were approved by research ethics committees (RECs) are often published only partially, with a substantial time lag or not at all. This study examined existing procedures of RECs in the European Union to monitor and prevent incomplete registration of trials and selective reporting of trial results. It further investigated opinions of REC members about the need to update current legislation on this matter. Methods: Web-based survey on members of RECs in 22 European countries. Results: Over 90 percent of respondents agreed that the incomplete publication of trial results had a strong or somewhat negative impact on public health and on healthcare professionals’ trust in the validity of clin...

【 授权许可】

CC BY