Branched-Chain Amino Acid Levels Are Related with Surrogates of Disturbed Lipid Metabolism among Older Men

Frontiers in Medicine

Urho M. Kujala¹ 

关键词: branched-chain amino acids;    metabolic disease;    tricarboxylic acid cycle;    lipid oxidation;    mitochondria;    energy metabolism;   

DOI  :  10.3389/fmed.2016.00057

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Aims/hypothesisExisting studies suggest that decreased branched-chain amino acid (BCAA) catabolism and thus elevated levels in blood are associated with metabolic disturbances. Based on such information, we have developed a hypothesis how BCAA degradation mechanistically connects to tricarboxylic acid cycle, intramyocellular lipid storage, and oxidation, thus allowing more efficient mitochondrial energy production from lipids as well as providing better metabolic health. We analyzed whether data from aged Finnish men are in line with our mechanistic hypothesis linking BCAA catabolism and metabolic disturbances.

【 授权许可】

CC BY