Glycemic Control with Ipragliflozin, a Novel Selective SGLT2 Inhibitor, Ameliorated Endothelial Dysfunction in Streptozotocin-Induced Diabetic Mouse

Frontiers in Cardiovascular Medicine

Hotimah Masdan Salim¹ 

关键词: SGLT2 inhibitor;    hyperglycemia;    endothelial function;    inflammation;    oxidative stress;   

DOI  :  10.3389/fcvm.2016.00043

学科分类：心脏病和心血管学

来源: Frontiers

【 摘 要 】

BackgroundEndothelial dysfunction caused by increased oxidative stress is a critical initiator of macro- and micro-vascular disease development in diabetic patients. Ipragliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor, offers a novel approach for the treatment of diabetes by enhancing urinary glucose excretion. The aim of this study was to examine whether ipragliflozin attenuates endothelial dysfunction in diabetic mice.

【 授权许可】

CC BY