Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Permissive Hypercapnia

Frontiers in Pediatrics

Sarah Gentner¹ 

关键词: permissive hypercapnia;    bronchopulmonary dysplasia;    pulmonary inflammation;    tracheal aspirates;    preterm infants;   

DOI  :  10.3389/fped.2017.00246

学科分类：儿科学

来源: Frontiers

【 摘 要 】

BackgroundVentilator-induced lung injury is considered to be a main factor in the pathogenesis of bronchopulmonary dysplasia (BPD). Optimizing ventilator strategies may reduce respiratory morbidities in preterm infants. Permissive hypercapnia has been suggested to attenuate lung injury. We aimed to determine if a higher PCO2 target range results in less lung injury compared to the control target range and possibly reduces pro-inflammatory cytokines and acid sphingomyelinase (ASM) in tracheal aspirates (TA), which has not been addressed before.

【 授权许可】

CC BY