Obstructive Sleep Apnea Syndrome in Children with 22q11.2 Deletion Syndrome after Operative Intervention for Velopharyngeal Insufficiency

Frontiers in Pediatrics

David Jeffrey Crockett¹ 

关键词: obstructive sleep apnea;    velopharyngeal insufficiency;    velopharyngeal dysfunction;    22q11.2 deletion syndrome;    velocardiofacial syndrome;    DiGeorge syndrome;    pharyngeal flap;    Furlow palatoplasty;   

DOI  :  10.3389/fped.2014.00084

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Introduction: Surgical treatment of velopharyngeal insufficiency (VPI) in 22q11.2 deletion syndrome is often warranted. In this patient population, VPI is characterized by poor palatal elevation and muscular hypotonia with an intact palate. We hypothesize that 22q11.2 deletion patients are at greater risk of obstructive sleep apnea (OSA) after surgical correction of VPI, due, in part, to their functional hypotonia, large velopharyngeal gap size, and the need to surgically obstruct the velopharynx.

【 授权许可】

CC BY