Multimodal Optical Medical Imaging Concepts Based on Optical Coherence Tomography

Frontiers in Physics

Leitgeb, Rainer A.¹  Baumann, Bernhard² 

[1] Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria;Christian Doppler Laboratory for Innovative Optical Imaging and Its Translation to Medicine, Medical University of Vienna, Austria

关键词: Multimodal Imaging;    optical coherence tomography (OCT);    optical coherence tomography angiography;    Polarization sensitivity;    Spectroscopic analysis;    non-linear optics;    RAMAN microscopy;    photoacoustic imaging;    standardization;    OCT elastography;    Doppler OCT;   

DOI  :  10.3389/fphy.2018.00114

学科分类：物理（综合）

来源: Frontiers

【 摘 要 】

Optical medical imaging techniques in general exhibit outstanding resolution and molecule-specific contrast. They come however with a limited penetration in depth and small field of view. Multimodal concepts help to combine complementary strengths of different imaging technologies. The present article reviews the advantages of optical multimodal imaging concepts using optical coherence tomography (OCT) as core technology. In particular we first discuss polarization sensitive OCT, Doppler OCT and OCT angiography, OCT elastography and spectroscopic OCT as intramodal concepts. To highlight intermodal imaging concepts, we then chose the combination of OCT with photoacoustics, and with non-linear optical microscopy. The selected multimodal concepts and their particular complementary strengths and applications are discussed in detail. The article concludes with notes on standardization of OCT imaging and multimodal extensions.

【 授权许可】

CC BY