Мукозальный иммунитет против патогенов и опухолей с участием системы «лектины пробиотиков - гликополимеры»

Acta Biomedica Scientifica

М. В. Лахтин¹  В. М. Лахтин¹  С. С. Афанасьев¹  В. А. Алешкин¹ 

[1] ФБУН «Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского» Роспотребнадзора

关键词: слизистая;    врожденный иммунитет;    пробиотические лектины;    лектиновые системы;    синтетические гликополимеры;    муцины;    микробиоценоз;    биотопы;    патогены;    опухолеподобные клетки;   

DOI  :  

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

The overview of own works is devoted to the new insights to mucosal innate immunity functioning. We described multifunctional lectin systems of probiotic bacteria (LSPB) and their complexes which recognize a wide spectrum of selected glycoconjugates. LSPB (separately or in combinations with other antimicrobials and antipathogen factors) are important contributors to biotope distant protection against pathogens. Being metabolomebiotics, LSPB form reversible complexes to natural and artificial glycopolymers of mucin type that allows building on duty dynamic network of directed cascades of replies of mucosal innate immunity. Probiotic molecular-cellular network "LSPB - glycopolymers" serves as an important synergistic system participating in biotope microbiocenosis antipathogen resistance and in Cross-Talking communications with human protective cells and systems to support prolonged healthy status of mucosa. This network influences mucosa pores, affine texture, tropism and redistribution in biotope. Mucosal innate immunity strategies of LSPB and their complexes against microbial and viral pathogens, early tumor-like mucosal cells are proposed. Biological properties of artificial glycopolymers interacted in LS were compared.

【 授权许可】

CC BY