Кандидные маркеры болезней урогенитальных биотопов: реактивность к лектинам пробиотиков

Acta Biomedica Scientifica

В. М. Лахтин¹  В. А. Алёшкин¹  А. Л. Байракова¹  С. С. Афанасьев¹  М. В. Лахтин²  М. С. Афанасьев³ 

[1] ФБУН Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского Роспотребнадзора;ФБУН Московский научноисследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского Роспотребнадзора;ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России»

关键词: лектины пробиотиков;    лактобациллы;    бифидобактерии;    микробиоценозы;    патогены;    кандиды;    урогенитальный тракт;    мукозальный иммунитет;    болезни;    цервицит;   

DOI  :  10.29413/ABS.2018-3.1.7

学科分类：自然科学（综合）

来源: Scientific entre for Family Health and Human Reproduction Problems

【 摘 要 】

Possibilities of using eukaryotic microorganisms (Candida spp.) of microbiocenoses of mucosal open cavities as potential biomarkers of pathological states of biotopes were investigated. To identify biotopes characterizing Candida strains we used new promising natural glycoconjugate recognition agents -lectins that imitate the effect of probiotics. The lectins were isolated from cultures of probiotic strains of lactobacillus and bifidus bacteria characterizing and supporting probiotic compartment of microbiocenosis of human mucosal open cavities as part of endogen sensory system "lectins of probiotic microorganisms - opportunistic eukaryotic yeast-like fungi". The study was carried out on examples of cases of dysbiotic disorders in the composition of microbiocenoses against the background of pathologies of the urogenital tract of patients with established diagnosis. Results demonstrate the early (before development of visible inflammatory reactions) presence of changed Candida cells in pathological biotopes of urogenital tract indicating states of diseases characterizing with increased differentiating affinities and sensitivities of Candida to a panel of probiotic lectins. Probiotic lectins are perspective in combinative prognostics and diagnostics of pathological states of functional biotopes of human mucosal open cavities as well as for prophylaxis and therapy of such states by compensation of deficit or absence of probiotic microflora to support healthy balance of mucosal immunity, instead of probiotics or in combinations with probiotics, antibiotics and other antimicrobial agents, therapeutics, and factors. The data also perspective in study of pathological biotope states possessing risk of conversion into tumor-like landscapes.

【 授权许可】

CC BY