Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer

Frontiers in Medicine

Cesar Seigi Fuziwara¹ 

关键词: microRNA;    miR-17-92;    cancer;    transcription;    processing;   

DOI  :  10.3389/fmed.2015.00064

学科分类：医学（综合）

来源: Frontiers

【 摘 要 】

Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster’s oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional regulation of miR-17-92. Recent findings show that other oncogenic signaling pathways, such as those of Notch and Sonic Hedgehog, activate miR-17-92 in cancer. Notwithstanding, another layer of complexity has been added by the influence of the relevant primary miR-17-92 tertiary structure during processing to mature miRNA. In this review, we attempt to integrate current transcriptional and post-transcriptional knowledge to enhance our global understanding of the coordinated up-regulation of miR-17-92 in cancer.

【 授权许可】

CC BY