β-Arrestins 1 and 2 are critical regulators of inflammation:

Innate Immunity

HongkuanFan¹ 

关键词: β-Arrestins;    G protein-coupled receptors;    immune cells;    inflammation;    inflammatory diseases;   

DOI  :  10.1177/1753425913501098

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

β-Arrestins 1 and 2 couple to seven trans-membrane receptors and regulate G protein-dependent signaling, receptor endocytosis and ubiquitylation. Recent studies have uncovered several unanticipated functions of β-arrestins, suggesting that the role of β-arrestins in cell signaling is much broader than originally thought. It is now recognized that β-arrestins can transduce receptor signaling independent of G proteins. The expression of β-arrestins is differentially regulated in immune cells and tissues in response to specific inflammatory stimuli, and β-arrestins are critical regulators of the inflammatory response. This review will focus on β-arrestins in immune cells and the impact of altered expression on the pathogenesis of specific inflammatory diseases. Understanding the role of β-arrestins in inflammation may lead to new strategies to treat inflammatory diseases, such as sepsis, rheumatoid arthritis, asthma, multiple sclerosis, inflammatory bowel disease and atherosclerosis.

【 授权许可】

CC BY