Cell-based laboratory evaluation of coagulation activation by antineoplastic drugs for the treatment of lymphoid tumors:

SAGE Open Medicine

MisaeTsunaka¹ 

关键词: Vorinostat;    L-asparaginase;    doxorubicin;    tissue factor;    phosphatidylserine;    deep-vein thrombosis;   

DOI  :  10.1177/2050312116660936

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Objectives:Combining vorinostat, L-asparaginase, and doxorubicin (Dox) led to improved response rates in the treatment of lymphoid tumors. However, deep-vein thrombosis has been noted as one of the most serious side effects with these drugs, and how these regimens cause deep-vein thrombosis is unclear.Methods:We investigated the procoagulant effects of vorinostat, L-asparaginase, and doxorubicin in lymphoid tumors, focusing on tissue factor, phosphatidylserine, and antithrombin. The human vascular endothelial cell line EAhy926 as well as the lymphoid neoplastic cell lines HUT78 (cutaneous T-cell lymphoma), Molt4 (acute T-lymphoblastic leukemia), and Ramos (Burkitt lymphoma) were employed to investigate these procoagulant effects.Results:Vorinostat, L-asparaginase, and doxorubicin induced exposure of phosphatidylserine and procoagulant activity on the surface of lymphoid tumor cells. Vorinostat and doxorubicin also induced phosphatidylserine exposure and increased procoagulant activity on EAhy926 cells. Ex...

【 授权许可】

CC BY