Acta Biomedica Scientifica | |
ЛЕКТИНЫ В АНТИРАКОВЫХ СТРАТЕГИЯХ | |
М. В. Лахтин1  В. М. Лахтин1  В. А. Алёшкин1  С. С. Афанасьев1  М. С. Афанасьев2  | |
[1] ФБУН «Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского» Роспотребнадзора;ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России | |
关键词: злокачественные опухоли; лектины; гликоконъюгаты; адъюванты; дендритные клетки; макрофаги; М-клетки; NK-клетки; врождённый иммунитет; субпопуляции клеток; межклеточные коммуникации; антираковая терапия; антираковые вакцины; | |
DOI : 10.29413/ABS.2018-3.4.11 | |
学科分类:自然科学(综合) | |
来源: Scientific entre for Family Health and Human Reproduction Problems | |
【 摘 要 】
The published during last few years data concerning communicative role of lectins (proteins and their complexes which recognize carbohydrates, glycoconjugates and their patterns) in on-duty supporting and increasing anticancer status of human immunity are analyzed. Examples of lectin-(glycoconjugate pattern) strategies, approaches and tactic variants in study and development of anticancer treatments, principle variants of therapy, possible vaccines in 35 cases of blood connected tumors (leukemia, lymphomas, others), solid tumors (carcinomas, sarcoma, cancers of vaginal biotopes, prostate, bladder, colon, other intestinal compartments, pancreas, liver, kidneys, others) and cancer cell lines are described and systemized. The list of mostly used communicative lectins (pattern recognition receptors, their soluble forms, other soluble lectins possessing specificities of importance) involving in key intercellular cascades and pathway co-functioning is presented. The regulation of resulting expression of distinct active lectins (available and hetero/di/oligomeric forms) and their interaction to adequate glycoconjugate patterns as well as influence distribution of co-functioning lectins and antigens CD between populations and subpopulations of antigen-presented cells (dendritic cells cDC, mDC, moDC, pDC; macrophages M2 and M1), mucosal M-cells, NK-cells play key role for choice and development of anticancer complex procedures increasing innate and innate-coupled immune responses. Prospects of (receptor lectin)-dependent intercellular communications and targeting glycoconjugate constructions into innate immunity cells for therapy of cancer and development of anticancer vaccines are evaluated and discussed.
【 授权许可】
CC BY
【 预 览 】
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