HIV virologic response better with single-tablet once daily regimens compared to multiple-tablet daily regimens:

SAGE Open Medicine

Shashi NKapadia¹ 

关键词: HIV;    antiretroviral therapy;    sexually transmitted infections;    fixed-dosed combinations;    single-tablet regimens;   

DOI  :  10.1177/2050312118816919

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Background:Single-tablet regimens are preferred prescription choices for HIV treatment, but there are limited outcomes data comparing single-tablet regimens to multiple-tablet regimens.Methods:We retrospectively assessed treatment-naïve patients at a single urban HIV clinic in the United States for viral load suppression at 6 and 12 months after initiating either single-tablet or multiple-tablet regimens. Multivariate regression was performed to obtain relative risks and adjust for potential confounders.Results:Of 218 patients, 47% were on single-tablet regimens and 53% on multiple-tablet regimens; 77% of single-tablet regimen patients had undetectable viral load at 6 months compared to 61% of multiple-tablet regimen patients (p = 0.012). At 12 months, 82% on single-tablet regimens and 66% on multiple-tablet regimens (p = 0.019) had undetectable viral load. Relative risk of any detectable viral load was 1.6 (95% confidence interval: 1.1–2.5) for patients on multiple-tablet regimens compared to single-tabl...

【 授权许可】

CC BY