Vitamin D in individuals before onset of rheumatoid arthritis - relation to vitamin D binding protein and its associated genetic variants

BMC Rheumatology

Linda Johansson¹  ä¹  rlestig¹  Johan Hultdin²  Evelina Nygren²  -Dahlqvist²  Lisbeth Ä⁴  Mikael Brink⁴  Solbritt Rantapä⁴ 

[1] University, Umeå, Sweden;Department of Medical Biosciences, Clinical Chemistry, UmeåDepartment of Public Health and Clinical Medicine/ Rheumatology, Umeå

关键词: Rheumatoid arthritis;    Vitamin D;    Vitamin D binding protein;    Pre-symptomatic individuals;    Case-control study;   

DOI  :  10.1186/s41927-018-0033-8

学科分类：内科医学

来源: BioMed Central

【 摘 要 】

Vitamin D has been implicated as being involved in the aetio-pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA). Previous studies present contradictory results. Vitamin D binding protein (DBP), the major transport protein, is also involved in various inflammatory processes. The aim of this study was to investigate the relationship between circulating levels of 25-hydroxyvitamin D [25(OH) D], DBP and polymorphisms in group-specific component (GC) in pre-symptomatic individuals and matched controls within prospective cohorts of the Northern Sweden. Blood samples donated to the Medical Biobank prior to the onset of symptoms of RA (n = 515, mean [SD] time before the onset of symptoms 6.2 [9.3] years) and from matched (2:1) population-based controls (n = 267) were used. Plasma 25(OH) vitamin D levels were analyzed using liquid chromatography tandem-mass spectrometry and DBP levels were analyzed using enzyme-linked immunosorbent assay. GC polymorphisms (rs4588 and rs7041) were analyzed with TaqMan assays (Applied Biosystems). Levels of 25(OH) D or DBP were not statistically different between pre-symptomatic individuals and controls in a crude, or a multiple-adjusted logistic regression model. However, an increased risk for future RA was found in females of DBP (OR 1.014 [95%CI 1.001–1.028]) per 10 mg/L adjusted for carriage of the minor allele of rs4588, in a multiple-adjusted model (p < 0.05). This study indicated that vitamin D is not associated with the future risk of RA although increasing levels of DBP were however, associated with an increased risk of disease in females carrying the minor allele of a DBP encoding SNP.

【 授权许可】

CC BY